Roasted Aroma 2-ethoxy-3-methylpyrazine CAS NO.32737-14-7 FEMA 3569

2-Ethoxy-3-methylpyrazine, identified by the CAS number 32737-14-7 and FEMA number 3569, is a highly valued alkoxypyrazine that contributes distinctive nutty, roasted, and earthy notes to the world of flavors and fragrances . With the molecular formula C₇H₁₀N₂O and a molecular weight of 138.17 g/mol, this heterocyclic compound is a member of the pyrazine family, renowned for its potent olfactory properties even at extremely low concentrations . It typically appears as a colorless to pale yellow clear liquid with a powerful, characteristic odor profile .

The sensory signature of 2-Ethoxy-3-methylpyrazine is particularly notable for its rich and complex nuances. It is frequently described as having a nutty character reminiscent of hazelnut and roasted almonds, often complemented by subtle pineapple-like and earthy undertones . This compound is also naturally present in foods such as peas and potatoes, contributing to their authentic volatile profiles . Its unique aroma makes it a critical component for flavorists aiming to recreate or enhance roasted, nutty, and savory profiles in a wide array of products .

In the flavor and fragrance industry, 2-Ethoxy-3-methylpyrazine (FEMA 3569) is primarily utilized as a flavoring agent to impart authentic hazelnut, almond, and roasted notes . It is widely used in the formulation of flavors for snacks, bakery products, beverages, and confectionery. Beyond flavors, its pleasant aroma characteristics also make it a valuable component in fragrance formulations for perfumes, air fresheners, and household products .

The physical properties of 2-Ethoxy-3-methylpyrazine are well-documented. It has a density of approximately 1.036-1.039 g/mL at 20°C . Its boiling point is reported around 180-181°C at 760 mmHg, with a lower value of 75°C at reduced pressure (8 Torr) . The compound has a flash point of approximately 150°F (65.6°C) and a refractive index of around 1.493-1.497 at 20°C . It is typically soluble in alcohol and has a water solubility of approximately 2378 mg/L at 25°C . According to regulatory information, commercial grades often consist of a mixture of isomers, with the named substance typically comprising at least 82% 2-ethoxy-3-methylpyrazine, alongside secondary components like 2-ethoxy-5-methylpyrazine (CAS 67845-34-5) or 2-ethoxy-6-methylpyrazine (CAS 53163-97-6) .

As a food additive, 2-Ethoxy-3-methylpyrazine (FEMA 3569) is recognized as safe for use as a flavoring agent by major regulatory bodies. It holds JECFA number 793, confirming its safety evaluation by the Joint FAO/WHO Expert Committee on Food Additives, which concluded no safety concern at current levels of intake . It is also included in the EU Flavour Information System with FL Nos. 14.067 and 14.109, and is approved by the Council of Europe (Number 11921) . When sourcing this compound, it is essential to obtain it from reputable suppliers who can provide certificates of analysis to ensure high purity (typically ≥98%) and compliance with food-grade standards .

Emerging research also explores potential applications beyond flavor, including pharmaceutical and agrochemical development, where pyrazine derivatives are investigated for their bioactive properties . However, its primary and most established role remains in creating authentic and appealing flavor and fragrance experiences.

In summary, 2-Ethoxy-3-methylpyrazine (CAS 32737-14-7) is a potent and versatile molecule whose characteristic hazelnut, almond, and earthy notes make it an indispensable tool for flavorists and perfumers seeking to add depth, warmth, and realism to their creations.